发明名称 PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES
摘要 The invention relates to a process for the preparation of a compound of formula (I);;or a salt thereof.
申请公布号 US2015025249(A1) 申请公布日期 2015.01.22
申请号 US201414509763 申请日期 2014.10.08
申请人 Hoffmann-La Roche Inc. 发明人 Puentener Kurt;Scalone Michelangelo
分类号 C07D413/12 主分类号 C07D413/12
代理机构 代理人
主权项 1. A process for the preparation of a compound of formula (I) or a salt thereof, wherein a compound of formula (II) or a salt thereof is hydrogenated (e) in the presence of a catalyst comprising iridium; or (f) in the presence of a catalyst comprising ruthenium and a compound of: formula (IV), or formula (VII), wherein R3 is alkyl, cycloalkyl or aryl; R4 is cycloalkyl, aryl or heteroaryl; R5 is cycloalkyl or aryl; R6 is cycloalkyl or aryl; R7 is cycloalkyl or aryl; R8 is cycloalkyl or aryl; and R9 is cycloalkyl or aryl.
地址 Little Falls NJ US