Methods of renal cell carcinoma prognosis and treatment selection with carbonic anhydrase IX

摘要

The present invention provides methods of aiding in a renal cell carcinoma prognosis that include quantifying expressed carbonic anhydrase in samples derived from renal cell carcinoma patients. The methods also identify patients that are likely to respond positively to selected courses of treatment. The invention further provides related computer program products.

主权项

1. A method of providing a prognosis for survival for a human subject diagnosed with metastatic renal clear cell carcinoma, comprising:
(a) obtaining a sample of a renal tumor or of a metastatic lesion of the renal tumor of the subject; (b) detecting expression of a carbonic anhydrase IX (CAIX) protein of SEQ ID NO:2 in the sample by immunohistochemical staining or immunoassay using an antibody that specifically binds to the CAIX protein of SEQ ID NO:2; (c) quantifying the percentage of the sample that is positive for expression of the CAIX protein; (d) identifying the subject as having a worse prognosis for survival if ≦85% of the sample expresses the CAIX protein or identifying the subject as having a better prognosis for survival if >85% of the sample expresses the CAIX protein; and (e) planning a therapy for the subject according to the prognosis.