| 摘要 |
PROBLEM TO BE SOLVED: To provide crystalline solvates useful in the treatment of abnormal cell growth in mammals.SOLUTION: This invention relates to crystalline solvates of (10R)-7-amino-12-fluoro-2,10,16- trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benz- oxadiazacyclotetradecine-3-carbonitrile, useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to: pharmaceutical compositions comprising such crystalline solvates; and methods of using such solvates and compositions in the treatment of abnormal cell growth in mammals, especially humans. |
