Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof

摘要

This invention relates to a method of obtaining antibodies specific to a population of T-lymphocytes (T cells) restricted by V beta gene usage. The invention also relates to the antibodies obtained and to methods of using them. According to the invention, T cells are incubated with an effective amount of a superantigen under conditions and for a time sufficient to allow division and growth of T-cells reactive to the superantigen. The incubated T-cells are injected into a mammal, and thereafter serum containing antibodies specific to the incubated and injected T-cells is removed from the mammal.