| 发明名称 |
(S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use |
| 摘要 |
Doc nt-5-l/29/2013 This invention relate to S-MNTX, methods of producing S-MNTX, pharmaceutical preparations comprising S-MNTX and methods for their use. N0 MeNO H BrO R-MNTX S-MNTX Fig. 1 Me'N BBr e...-N O 0 O NMP, CC3 AUTOCLAVE, OMe OH70'C 10Br OH Br OH Me...N ION Me.N O 0 EXCHANGE 0 0 OH OH 3 S-MNTX 1 -- OXYCODONE 2 - OXYMORPHONE 3 -IODIDE SALT OF S-MNTX Fig.2 |
| 申请公布号 |
AU2013200437(B2) |
申请公布日期 |
2015.01.15 |
| 申请号 |
AU20130200437 |
申请日期 |
2013.01.29 |
| 申请人 |
PROGENICS PHARMACEUTICALS, INC. |
发明人 |
VERBICKY, CHRISTOPHER;WAGONER, HOWARD;BOYD, THOMAS;SANGHVI, SUKETU;ANDRUSKI, STEPHEN |
| 分类号 |
C07D489/08;A61K31/485;A61P1/12;A61P25/04 |
主分类号 |
C07D489/08 |
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