| 主权项 |
1. A compound of Formula (I) wherein R1, R2, R3 are each independently H, linear or branched C1-C6-alkyl, linear or branched C1-C6-alkoxy, Hal, or hydroxyl; Ra, Rb are each independently H, Hal, hydroxy or A; Q denotes a 6-membered aromatic group or a 5-6-membered heteroaromatic group having 1 to 4 heteroatoms independently selected from N, O and S; R4 denotes G, OG, SG, OCHF2, OCF2CHF2, NR5G, —COOG, or OCOG; each R5 is independently H or a linear or branched alkyl having 1 to 6 carbon atoms; each G is independently —CH3, —CF3, —CH2-A, Het, Cyc, Ar, —CH2-Het, —CH2-Cyc, —CH2—Ar, Hal, or hydroxy; each Hal is independently F, Cl, Br or I; each A is independently a linear or branched carbon chain having 1 to 6 carbon atoms, wherein 1 to 3 non adjacent —CH2-groups may be independently from each other substituted by a group selected from O, NR5, S, SO, SO2, CO, and wherein 1 to 5 hydrogen atoms may be independently from each other substituted by Het, Cyc, Ar, or Hal; each Het is independently a saturated, unsaturated or aromatic ring, each of which is monocyclic, bicyclic, or fused-bicyclic, and having 3- to 8-members and containing 1 to 4 heteroatoms independently selected from N, NR5, O, S, CO, SO or SO2, each of which may be substituted by 1 to 3 substituents independently selected from A, Hal, OH and Het1; Het1 denotes a 4, 5 or 6 membered carbocyclic ring wherein 1 or 2 carbon atom are replaced by Oxygen atoms. each Ar is independently a 6-membered carbocyclic aromatic ring or a fused or non fused byclic aromatic ring, and optionally substituted by 1 to 3 substituents independently selected from A or Hal; each Cyc is independently a saturated or unsaturated carbocyclic ring having from 3 to 8 carbon atoms and optionally substituted by 1 to 3 substituents independently selected from A or Hal; and/or pharmaceutically acceptable derivatives, tautomers, salts, solvates and stereoisomers thereof. |
