| 摘要 |
The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function. |
| 申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
PALANI, ANANDAN;HUANG, XIANHAI;BRUBAKER, JASON;PETERSON, SCOTT, L.;BUTCHER, JOHN, W.;CLOSE, JOSHUA, T.;MARTINEZ, MICHELLE;MACCOSS, RACHEL, NICOLA;JUNG, JOON, O.;SILIPHAIVANH, PHIENG;ZHANG, HONGJUN;ASLANIAN, ROBERT, G.;BIJU, PURAKKATTLE, JOHNY;DONG, LI;HUANG, YING;MCCORMICK, KEVIN, D.;SHAO, NING;ZHOU, WEI |
