发明名称 |
ANTIOXIDANT CAMPTOTHECIN DERIVATIVES AND ANTIOXIDANT ANTINEOPLASTIC NANOSPHERES THEREOF |
摘要 |
The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant camptothecin nanosphere prodrugs and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these antioxidant camptothecin nanosphere prodrugs for the preparation of delivery devices of other pharmaceuticals and/or drugs. Additionally, methods of treating cancer with the camptothecin and antioxidant derivatives of camptothecin analogs, and nanometer-sized camptothecin prodrugs are also provided. |
申请公布号 |
EP2370435(B1) |
申请公布日期 |
2015.01.07 |
申请号 |
EP20090828387 |
申请日期 |
2009.11.24 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
YU, JOHN, S.;LEE, BONG SEOP |
分类号 |
C07D471/00 |
主分类号 |
C07D471/00 |
代理机构 |
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