| 发明名称 |
Process for the preparation of esomeprazole magnesium dihydrate |
| 摘要 |
<p>A process for preparing (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole comprising oxidizing 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio-1H-benzimidazole in the absence of a base and in the presence of an oxidizing agent and a chiral titanium complex.</p> |
| 申请公布号 |
EP2186807(B1) |
申请公布日期 |
2015.01.07 |
| 申请号 |
EP20090178721 |
申请日期 |
2008.02.21 |
| 申请人 |
CIPLA LIMITED |
发明人 |
RAO, DHARMARAJ, RAMACHANDRA;KANKAN, RAJENDRA, NARAYANRAO;PATHI, SRINIVAS, LAXMINARAYAN;BANGALORE, SUMANA, GOPALAKRISHNA |
| 分类号 |
C07D401/12;A61K31/4427;A61P1/04 |
主分类号 |
C07D401/12 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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