Process and apparatus for preparing a diagnostic or therapeutic agent

摘要

Provided are a preparation process of a diagnostic or therapeutic agent having a step of adding, to a first fine emulsion having a particle size of 0.5 μm or less prepared by applying a predetermined pressure to a first mixture containing a first hydrophobic compound, an emulsifying agent, and an aqueous phase, a second hydrophobic compound compatible with the first hydrophobic compound, thereby preparing a second mixture; and a step of stirring and shaking the second mixture in a hermetically sealed state, thereby embedding the second hydrophobic compound in the first fine emulsion to prepare a second fine emulsion having a particle size of 0.5 μm or less; a diagnostic or therapeutic agent prepared by the process; and an apparatus for carrying out the process.

主权项

1. A method of preparing an emulsion containing hydrocarbons, comprising:
preparing a first fine emulsion having a particle diameter of 0.5 μm or less by applying a pressure to a first mixture comprising a first compound which contains at least one compound selected from the group consisting of linear hydrocarbons, branched hydrocarbons, linear fluorinated hydrocarbons, and branched fluorinated hydrocarbons, an emulsifying agent, and an aqueous phase; storing the prepared first fine emulsion in a vessel in a hermetically sealed state; adding a second compound which contains at least one compound selected from the group consisting of linear hydrocarbons, branched hydrocarbons, linear fluorinated hydrocarbons, and branched fluorinated hydrocarbons, to the prepared first fine emulsion stored in the vessel in the hermetically sealed state, thereby preparing a second mixture; and stirring, in the vessel, the second mixture in the hermetically sealed state to embed the second compound in the first fine emulsion, thereby obtaining a second fine emulsion, which contains both the first compound and the second compound, having a particle diameter of 0.5 μm or less, wherein the second compound has a boiling point which is less than a boiling point of the first compound.