Protein Target Complex

摘要

The present invention relates to a method for labeling or targeting cells whose plasma membrane has lost integrity, such as dead cells, such as for discriminating between live cells and cells whose plasma membrane has lost integrity; to an embodiment of the method for determining one or more values of one or more parameters of cells of a biological sample; to use of the method in an assay for screening drugs for therapy such as cancer therapy; to use of the method to monitor and/or determine the effectiveness of a therapy; to an assay kit; to a complex; to the complex for use as a medicament; to the complex for use in treatment of cancer(s) and/or plaque(s) and/or regeneration and/or supporting the immune system; and, to a dead cell.

主权项

1. A method for labeling or targeting cells whose plasma membrane has lost integrity, such as dead cells, such as for discriminating between live cells and cells whose plasma membrane has lost integrity, wherein the method comprises:
(a) providing a population of cells comprising cells whose plasma membrane has lost integrity, and a first intracellular protein; (b) providing a first non-activated extracellularly applied first compound, wherein the first compound is substantially unable to cross a healthy cell membrane; (c) chemically/physically/biologically interacting the first compound and the first protein in a cell whose plasma membrane has lost integrity, and (d) performing a measurement to determine an amount of interaction between the first compound and the cell whose plasma membrane has lost integrity.