| 摘要 |
<p>The present invention belongs to the technical field of biomedical high molecular polymer materials and discloses an amphiphilic 4/6 miktoarm star-shaped pH-responsive copolymer with a number-average molecular weight of 30000-54000 g/mol. The present invention also discloses a method for preparing the copolymer: mixingε-caprolactone, stannous octoate and a small molecule initiator, reacting at 110-140°C for 24-48 h, distilling under reduced pressure, precipitating, filtering and drying to obtain a polycaprolactone macroinitiator; dissolving the polycaprolactone macroinitiator, diethylaminoethyl methacrylate, hexamethyl triethylenetetramine and copper bromide in toluene, adding stannous octoate after stirring, and reacting at 60-90°C for 5-12 h; and adding methacrylic acid ester of mono-methoxylated polyethylene glycol and continuously polymerizing for 5-12 h, removing the catalyst, filtering and postreating the filtrate to obtain the amphiphilic 4/6 miktoarm star-shaped pH-responsive copolymer, which is used to prepare a micellar system for loading water-insoluble drugs.</p> |
