| 发明名称 |
ANTISENSE OLIGOMERS AND CONJUGATES TARGETING PCSK9 |
| 摘要 |
The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders. |
| 申请公布号 |
WO2014207232(A1) |
申请公布日期 |
2014.12.31 |
| 申请号 |
WO2014EP63757 |
申请日期 |
2014.06.27 |
| 申请人 |
SANTARIS PHARMA A/S |
发明人 |
ALBÆK, NANNA;HEDTJÄRN, MAJ;LINDHOLM, MARIE;NIELSEN, NIELS FISKER;PETRI, ANDREAS;RAVN, JACOB |
| 分类号 |
C12N15/113;A61K31/712;A61P3/06 |
主分类号 |
C12N15/113 |
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