Topical delivery of viscous medications for the treatment of diseases associated with chronic sinusitis

摘要

A medication or combination of medications for the treatment of a disease involving the sinuses is incorporated into a sterile medical gel. The viscosity of the gel or the adhesion of the gel to the patient's sinus cavity allows the gel to be maintained in the cavity for a sufficient length of time for treatment of the affected area. This reduces the amount of wasted medication that would otherwise result from other topical methods.

主权项

1. A medicated gel, comprising:
a sterile viscous fluid having a viscosity sufficient to be maintained within a human paranasal sinus cavity after insertion; and a medication dispersed in the sterile viscous fluid; wherein the pH of the medicated gel is not adjusted by the addition of any acids, bases, or buffers, and the osmolality of the medicated gel is not adjusted by addition of any salts; wherein the sterile viscous fluid comprises hydroxyethylcellulose, and the medication comprises tobramycin or mometasone.