发明名称 |
OPTIMIZED EARLY-LATE PROMOTER COMBINED WITH REPEATED VACCINATION FAVORS CYTOTOXIC T CELL RESPONSE AGAINST ANTIGENS IN REPLICATION DEFICIENT RECOMBINANT VIRUS VACCINES |
摘要 |
The invention is drawn to compositions and methods for the induction of a strong CD8 T cell response to a specific antigen(s). The combination of an early/late hybrid promoter directing strongly enhanced early expression of a neoantigen with at least three immunization rounds resulted in a highly efficient neoantigen-specific CD8 T cell response. This combination reversed the immunodominance hierarchy and converted a moderately immunogenic and subdominant CD8 T cell epitope into the immunodominant epitope. |
申请公布号 |
ZA201106655(B) |
申请公布日期 |
2014.12.23 |
申请号 |
ZA20110006655 |
申请日期 |
2011.09.12 |
申请人 |
BAVARIAN NORDIC A/S |
发明人 |
BRINKMANN KAY;BAUR KAREN;HAUSMANN JURGEN |
分类号 |
A61K;C07K;C12N |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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