| 发明名称 | Proangiogenic compositions, method for preparing same, and uses thereof | ||
| 摘要 | The invention relates to novel proangiogenic compositions, to the method for preparing same, and to the uses thereof, particularly for preventing or treating any disease causing ischemic-type complications. | ||
| 申请公布号 | US8916144(B2) | 申请公布日期 | 2014.12.23 |
| 申请号 | US201113636582 | 申请日期 | 2011.03.28 |
| 申请人 | Institut des Vaisseaux et du Sang;Universite Paris Diderot Paris—7 | 发明人 | Tobelem Gérard;Silvestre Jean-Sébastien |
| 分类号 | C12N5/078;A61K35/14;A61P9/10;A61K35/48;A61K35/28;A61K47/42;A61K38/17;A61K9/00 | 主分类号 | C12N5/078 |
| 代理机构 | Ostrolenk Faber LLP | 代理人 | Ostrolenk Faber LLP |
| 主权项 | 1. A proangiogenic composition, formed by a process comprising: (i) obtaining peripheral blood mononuclear cells (MNCs) having receptors selected from the group comprising of EphAs and EphBs; (ii) placing the peripheral blood mononuclear cells (MNCs) in a suitable medium; and (iii) activating the peripheral blood mononuclear cells (MNCs) placed in the suitable medium by contact with ephrin-B which is associated with at least one of a stabilizing and a bonding molecule in order to stimulate the proangiogenic activity of said peripheral blood mononuclear cells (MNCs). | ||
| 地址 | FR | ||