| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide further and improved approaches for overcoming the family specificity of protection afforded by NMB1870, and to use these approaches for providing immunity against meningococcal disease and/or infection, particularly for serogroup B.SOLUTION: The invention provides a polypeptide comprising a modified amino acid sequence of a first loop family of NMB1870, where the modified sequence includes at least one (e.g. 1, 2, 3, 4, 5, 6 or 7) surface loop sequence from a second family of NMB1870 in place of a surface loop sequence from the first family.</p> |
