PREPARATION OF PROTECTIVE ANTIGEN FROM BACILLUS ANTHRACIS
摘要
A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75 % identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinant Bacillus anthracis Protective Antigen (rPA); or a fragment of said nucleic acid sequence wherein said fragment encodes a fragment of recombinant Bacillus anthracis Protective Antigen (rPA). Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA or a fragment thereof. The invention further provides antigenic compositions and. corresponding methods and uses for inducing an immune response.
申请公布号
CA2570508(C)
申请公布日期
2014.12.16
申请号
CA20052570508
申请日期
2005.06.16
申请人
HEALTH PROTECTION AGENCY;DYNPORT VACCINE COMPANY LLC
发明人
BREHM, JOHN;MCENTEE, IAN;VINCENT, PHILIP;ALLISON, NIGEL;BREHM, ROSSALYN;JACK, GEORGE;HERBERT, MICHAEL;SOLOW, BARBARA T.;ARROYO, JUAN;LAPCEVICH, RANDALL K.