发明名称 |
PYRIDYLISOXAZOLE DERIVATIVES |
摘要 |
This invention offers isoxazole derivatives represented by the following formula (I) (see formula I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for -CH2-, -CO-, -O-, -NH- and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like. |
申请公布号 |
CA2656159(C) |
申请公布日期 |
2014.12.16 |
申请号 |
CA20072656159 |
申请日期 |
2007.06.26 |
申请人 |
ASKA PHARMACEUTICAL CO., LTD. |
发明人 |
HASUMI, KOICHI;OHTA, SHUJI;SAITO, TAKAHISA;SATO, SHUICHIRO;KATO, JUN-YA;SATO, JUN;SUZUKI, HIROYUKI;ASANO, HAJIME;OKADA, MAMI;MATSUMOTO, YASUHIRO;SHIROTA, KAZUHIKO |
分类号 |
C07D413/04;A61K31/4439;A61P1/04;A61P1/16;A61P3/10;A61P9/10;A61P9/12;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P15/06;A61P17/00;A61P17/06;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P25/28;A61P29/00;A61P31/00;A61P31/04;A61P31/06;A61P31/18;A61P35/00;A61P35/04;A61P37/02;A61P37/08;A61P43/00;C07D413/14 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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