Systems, devices, and methods for monitoring and analyzing research animal behavior before, during and after brain electrical stimulation

摘要

Described are systems, devices and methods for facilitating the delivery of stimulation to, and the monitoring and recording of physiological signals (e.g., electroencephalographic signals) from a research subject. Devices include a headmount that includes a cranial frame and a headstage, and a connection between the headmount and external equipment used for stimulation, monitoring, and/or recording that is robust physically and electrically to optimize stimulation, monitoring and recording even while the subject remains ambulatory. In some embodiments, a hinged headmount allows the configuration to be easily manipulated during attachment and any subsequent adjustment or reattachment procedures and permits easy access to any wires or other components implanted in the subject. In some embodiments, a flexible cable extends out from the headmount at an acute angle relative to a horizontal plane of the headmount, to optimize strain relief as the subject moves about while attached to any stimulation, monitoring and/or recording equipment.

主权项

1. A headmount for use with a non-human subject comprising:
a frame comprising a structural support configured to mount on a subject's cranium, the frame further comprising a top surface; a headstage comprising a hollow interior portion in which at least one circuit board and a connector in operable communication with the at least one circuit board is disposed, the headstage further comprising a lower surface; wherein the at least one circuit board is provided with elements configured to permit electrical connection with at least one electrode configured to be implanted in the subject; and a connection mechanism configured to establish a mechanical connection between the frame and the headstage, and to facilitate movement of the headmount between a closed arrangement wherein at least a portion of the top surface of the frame is in contact with at least a portion of the lower surface of the headstage, and an opened arrangement wherein the top surface of the frame is not in contact with the lower surface of the headstage.