RECOMBINANT ONCOLYTIC VIRUS EXPRESSING AN IFN BINDING PROTEIN

摘要

The present disclosure provides a recombinant interferon (IFN)-sensitive oncolytic rhabdovirus that includes a polynucleotide sequence encoding a soluble protein that binds to IFN-α, IFN-&bgr;, or both. The soluble protein is referred to herein as an "interferon binding protein". The interferon binding protein is secretable by a cell infected with the oncolytic rhabdovirus.