Use of NK-1 receptor antagonists in pruritus

摘要

The invention relates to methods for treating pruritus with an NK-1 receptor antagonist. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonist.

主权项

1. A method of treating chronic pruritus, said method comprising orally administering 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one or a pharmaceutically acceptable salt or solvate thereof to a patient in need of such treatment according to a schedule, said schedule comprising:
a) first administering at least one loading dose; and b) second administering at least one therapeutically effect maintenance dose;said maintenance dose is administered chronically and comprises a dosage from about 0.1 mg to about 7.5 mg.