| 发明名称 | Dpy-30 binding peptides | ||
| 摘要 | Disclosed are compositions and methods for modulating Dpy-30 binding activity. The compositions may include peptides or peptidomimetics thereof that are related to radial spoke protein 3 (RSP3) or absent, small, homeotic discs 2-like protein (Ash2L) and that bind to Dumpy-30 protein (Dpy-30). | ||
| 申请公布号 | US8907054(B2) | 申请公布日期 | 2014.12.09 |
| 申请号 | US201213569583 | 申请日期 | 2012.08.08 |
| 申请人 | Marquette University | 发明人 | Yang Pinfen;Sivadas Priyanka |
| 分类号 | C07K7/08;C07K14/00 | 主分类号 | C07K7/08 |
| 代理机构 | Andrus Intellectual Property Law, LLP | 代理人 | Andrus Intellectual Property Law, LLP |
| 主权项 | 1. A peptide of no more than 50 amino acids, the peptide comprising the amino acid sequence of SEQ ID NO:6 or comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:6, wherein the peptide binds to Dpy-30 with a Kd of less than 100 nM, and wherein the peptide is modified and the modification is selected from the group consisting of acylation, acetylation, formylation, lipolylation, myristoylation, palmitoylation, alkylation, isoprenylation, prenylation, and amidation. | ||
| 地址 | Milwaukee WI US | ||