The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
申请公布号
WO2014193800(A2)
申请公布日期
2014.12.04
申请号
WO2014US39519
申请日期
2014.05.27
申请人
THE JOHNS HOPKINS UNIVERSITY
发明人
CASELLA, JAMES, F.;BARRON-CASELLA, EMILY;KEEFER, JEFFREY, R.;FORTENBERRY, YOLANDA;PURVIS, SHIRLEY, H.
