METHODS AND COMPOSITIONS FOR DETECTING PROGRESSIVE HEARING LOSS

摘要

Methods and products for identifying a human subject as having or having an increased likelihood to develop otosclerosis hearing loss are provided. The method comprises (a) obtaining a suitable sample from the subject; (b) assaying the sample for the presence or absence of a mutation in: i) a FOXL1 polynucleotide encoding an amino acid corresponding to position 326 to position 330 of SEQ ID NO:2 or ii) a FOXL1 polypeptide encoded by said polynucleotide; and (c) identifying the subject as having or having an increased likelihood to develop otosclerosis hearing loss if said mutation is detected.