| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for treating disorders arising from hypogonadism, rheumatoid cachexia, cachexia due to burns, cachexia due to chemical agents, cachexia due to diabetes, diabetic nephropathy, Prader Willi syndrome, excessive TNF-α, and other muscle-related, metabolic and inflammatory disorders.SOLUTION: The method of the invention administers a pharmaceutical composition comprising a myostatin antagonist to subjects suffering from such disorders, where the myostatin antagonist is selected from follistatin, myostatin prodomain, GDF-11 prodomain, prodomain fusion proteins, antagonistic antibodies or antibody fragments that bind myostatin, antagonistic antibodies or antibody fragments that bind to the activin type IIB receptor, soluble activin type IIB receptor, soluble activin type IIB receptor fusion proteins, soluble myostatin analogs, oligonucleotides, small molecules, peptidomimetics, and myostatin-binding agents. |
