发明名称 |
PHARMACEUTICAL ANTIBODY COMPOSITIONS WITH RESISTANCE TO SOLUBLE CEA |
摘要 |
<p>The present invention relates to pharmaceutical compositions for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising an IgG1 antibody specifically binding to human CEA, wherein the variable region of said IgG1 antibody comprises at least (i) a CDR-H1 having the amino acid sequence "SYWMH" (SEQ ID NO: 29) and a CDR-H2 having the amino acid sequence "FIRNKANGGTTEYAASVKG" (SEQ ID NO: 28) and a CDR-H3 having the amino acid sequence "DRGLRFYFDY" (SEQ ID NO: 27) or (ii) a CDR-H1 having the amino acid sequence "TYAMH" (SEQ ID NO: 31) and a CDR-H2 having the amino acid sequence "LISNDGSNKYYADSVKG" (SEQ ID NO: 30) and a CDR-H3 having the amino acid sequence "DRGLRFYFDY" (SEQ ID NO: 27). Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the IgG1 antibody molecules bearing specificities for the human CEA antigen are disclosed.</p> |
申请公布号 |
EP1976885(B1) |
申请公布日期 |
2014.12.03 |
申请号 |
EP20060841100 |
申请日期 |
2006.12.21 |
申请人 |
AMGEN RESEARCH (MUNICH) GMBH |
发明人 |
RAU, DORIS;MANGOLD, SUSANNE;KUFER, PETER;RAUM, TOBIAS |
分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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