MANAGING FLUIDIC CONNECTIONS TO MICROFLUIDIC DEVICES

摘要

A system (e.g., a chromatography system) includes a rotor, a microfluidic device, a rotor driver, a clamping mechanism, and control electronics. The rotor defines a plurality of first fluid-conveying features. The micro fluidic device defines one or more channels and a plurality of second fluid-conveying features, in fluid communication with the one or more channels. The rotor driver is coupled to the rotor and is configured to rotate the rotor, relative to the microfluidic device, between a first position and a second position such that, in each of the positions, at least one of the first fluid-conveying features cooperates with at least one of the one or more channels to provide for fluid communication therebetween. The clamping mechanism is operable to provide a sealing force to establish a fluid-tight seal between the rotor and the microfluidic device.

主权项

1. A system comprising:
a rotor defining a plurality of first fluid-conveying features; a microfluidic device defining one or more channels and a plurality of second fluid-conveying features, in fluid communication with the one or more channels; a rotor driver coupled to the rotor and configured to rotate the rotor, relative to the microfluidic device, between a first position and a second position such that, in each of the positions, at least one of the first fluid-conveying features cooperates with at least one of the one or more channels to provide for fluid communication therebetween; a clamping mechanism operable to provide a sealing force to establish a fluid-tight seal between the rotor and the microfluidic device; and control electronics operatively associated with the clamping mechanism and configured to control operation of the clamping mechanism such that the sealing force is reduced during rotation of the rotor relative to the microfluidic device.