Analysis of substrates having agents deposited thereon

摘要

Improved analytical, diagnostic, monitoring, and other methods (and their associated devices) for evaluating the extent of deposition of an agent onto a substrate are described. Exemplary methods may be used in the in the monitoring of the dental health of patients or in the fast, efficient screening and/or characterization of formulations in terms of their use for depositing oral actives onto tooth surfaces. The methods involve the direct or in situ analysis of substrates, onto which agents are deposited, using Near-IR spectroscopy and/or UV spectroscopy.

主权项

1. A method for measuring deposition of an oral agent from a dentifrice on a substrate, the method comprising:
(a) contacting the substrate with the oral agent to deposit an amount of the oral agent thereon, wherein the substrate is coated with saliva and (b) analyzing the substrate using Near-Infrared Near-IR) spectroscopy or an Ultraviolet (UV) spectroscopy probe contained within a toothbrushwherein a wavelength used in step (b) is specific to said oral agent and wherein a reference signal of the dentifrice without the oral agent is subtracted from the analysis to provide an amount for the oral agent.