| 发明名称 | Galliated calcium phosphate biomaterials | ||
| 摘要 | The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7 (I) wherein 0<x<1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. ;It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants.;It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component.;It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption. | ||
| 申请公布号 | US8894958(B2) | 申请公布日期 | 2014.11.25 |
| 申请号 | US201012716850 | 申请日期 | 2010.03.03 |
| 申请人 | Centre National de la Recherche Scientifique (C.N.R.S.);University de Nantes;Graftys | 发明人 | Bujoli Bruno;Bouler Jean-Michel;Janvier Pascal;Khairoun Ibrahim;Schnitzler Verena;Mellier Charlotte |
| 分类号 | C01B15/16;C01B25/26;C09K3/00;C04B12/02;C04B28/34;A61L27/12;C04B103/00;C04B111/00 | 主分类号 | C01B15/16 |
| 代理机构 | Michael Best & Friedrich LLP | 代理人 | Michael Best & Friedrich LLP |
| 主权项 | 1. A galliated calcium-phosphate biomaterial comprising a compound selected from a gallium-doped phosphocalcic compound of formula (1): Ca(10.5-1.5x)Gax(PO4)7 (1) wherein 0≦x≦1 and characterized in that it crystallizes at least partially in the space group R3c with cell parameters varying in the following range, as a function of the Ga content: a=10.31-10.44 Å, c=37.15-37.5 Å, α=90°; β=90° and γ=120° and/or characterized by a Ca/P ratio comprised between 1.44 and 1.67 and an X-ray powder diffraction broad lines at 2θ˜26° (medium) and ˜32° (strong), and hydrates thereof. | ||
| 地址 | Paris FR | ||