| 主权项 |
1. A compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein:
D and Z are each independently absent or optionally substituted linear aliphatic group comprising zero to eight carbons;A and E are each independently absent or a cyclic group; wherein said each cyclic group is independently selected from the group consisting of aryl, heteroaryl, heterocyclic, C3-C8 cycloalkyl, and C3-C8 cycloalkenyl, each optionally substituted;T is absent or an optionally substituted aliphatic group;Wherein one to four of A, D, E, T and Z is absent;Ring B is a five-membered heteroaryl, wherein said heteroaryl is optionally substituted;R1 at each occurrence is independently selected from the group consisting of hydrogen, halogen, cyano, optionally substituted C1-C4 alkyl, —O—R11, —NRaRb, —C(O)R11, —CO2R11, and —C(O)NRaRb;R11 at each occurrence is independently hydrogen or optionally substituted C1-C8 alkyl;Ra and Rb at each occurrence are each independently selected from the group consisting of hydrogen, optionally substituted C1-C8 alkyl, and optionally substituted C2-C8 alkenyl; or Ra and Rb can be taken together with the nitrogen atom to which they are attached to form an optionally substituted heterocyclic or optionally substituted heteroaryl group;u is independently 1, 2, or 3;Q and J are each independently selected from: wherein is selected from: R3 and R4 at each occurrence are each independently selected from the group consisting of hydrogen, optionally substituted C1-C8 alkyl, optionally substituted C2-C8 alkenyl, and optionally substituted C3-C8 cycloalkyl; or alternatively, R3 and R4 can be taken together with the carbon atom to which they are attached to form optionally substituted C3-C8 cycloalkyl or optionally substituted heterocyclic;R5 at each occurrence is independently hydrogen, optionally substituted C1-C8 alkyl, or optionally substituted C3-C8 cycloalkyl;R6 is selected from the group consisting of —C(O)—R12, —C(O)—C(O)—R12, —S(O)2—R12, and —C(S)—R12;R12 at each occurrence is independently selected from the group consisting of —O—R11, —NRaRb, —R13, and —NRcRd; whereinR13 at each occurrence is independently selected from the group consisting of: hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, heterocyclic, aryl, and heteroaryl, each optionally substituted; andRc and Rd at each occurrence are each independently selected from the group consisting of hydrogen, —R13, —C(O)—R13, —C(O)—OR13, —S(O)2—R13, —C(O)N(R13)2, and —S(O)2N(R13)2;m is 0, 1, or 2;n is 1, 2, 3, or 4;X at each occurrence is independently selected from O, S, S(O), SO2, and C(R7)2; provided that when m is 0, X is C(R7)2; andR7 at each occurrence is independently selected from the group consisting of: hydrogen, halogen, cyano, —O—R11, —NRaRb, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted —C1-C4 alkyl, and optionally substituted C3-C8-cycloalkyl; or two vicinal R7 groups are taken together with the two adjacent atoms to which they are attached to form a fused, optionally substituted C3-C8 cycloalkyl or optionally substituted heterocyclic ring; or alternatively two geminal R7 groups are taken together with the carbon atom to which they are attached to form a spiro, optionally substituted C3-C8 cycloalkyl or optionally substituted heterocyclic ring. |
