IMIDAZOPYRROLIDINONE COMPOUNDS

摘要

The invention relates to compounds of formula (I):;;as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

主权项

1. The crystalline form A of 4-[5-(3-Chloro-2-fluoro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile, characterized by a x-ray powder diffraction pattern comprising 4 or more 2 theta values selected from the group consisting of 6.54±0.2, 14.29±0.2, 15.72±0.2, 16.78±0.2, 17.82±0.2, 19.41±0.2, 20.10±0.2°, 20.67±0.2, 23.65±0.2 and 25.82±0.2, at a temperature of about 22° C., in particular 16.78±0.2, 19.41±0.2, 23.65±0.2 and 25.82±0.2.