发明名称 |
EPITOPE VACCINE FOR LOW IMMUNOGENIC PROTEIN AND PREPARING METHOD AND USAGE THEREOF |
摘要 |
The present invention provides recombinant protein carrying an epitope. The recombinant protein has a skeleton structure from carrier protein, and a low immunogenic protein epitope is imported through splicing, replacement, and/or insertion to at least one molecular surface animo acid residue area of the carrier protein. The carrier protein has at least one T cell epitope, and the recombinant protein can effectively excite immunoreaction of an organism to the low immunogenic protein epitope. |
申请公布号 |
WO2014183649(A1) |
申请公布日期 |
2014.11.20 |
申请号 |
WO2014CN77522 |
申请日期 |
2014.05.14 |
申请人 |
SHANGHAI HYCHARM INC, |
发明人 |
LI, RONGXIU;ZHANG, LI;ZHONG, CONGHAO;CHENG, CHAO;ZHANG, LI;XU, AIZHANG;LU, WUGUANG |
分类号 |
C07K19/00;A61K39/385;A61P37/02;C12N1/00;C12N15/62;C12N15/63 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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