主权项 |
1. An injectable graft composition, comprising acellular extracellular matrix (ECM) comprising small intestine submucosa, said ECM comprising endogenous glycosaminoglycans (GAGs), transforming growth factor beta (TGF-β) and fibroblast growth factor-2 (FGF-2), said ECM further comprising an exogenously added iPS inducing factor,
wherein, when said composition is administered to damaged tissue comprising a cell selected from the group consisting of fibroblasts, amniotic cells, pancreatic β cells, mesenchymal stem cells, neural stem cells, mature B cells, stomach cells, liver cells, melanocytes, adipose stem cells, adipose stromal cells and keratinocytes, said cell expresses the phenotype of a pluripotent stem cell and forms an iPS cell, said iPS cell thereafter links to and interacts with said ECM, wherein said ECM induces differentiation of said iPS cell to a cardiomyocyte. |