发明名称 Topical antifungal agent
摘要 An anti-fungal agent for tinea comprising as active ingredient a compound having the skeleton of 2-(1H-pyrazol-1-yl)phenol represented by the following formula (I) or (II) or a salt thereof is provided;
申请公布号 US8889727(B2) 申请公布日期 2014.11.18
申请号 US201213982734 申请日期 2012.01.30
申请人 Meiji Seika Pharma Co., Ltd. 发明人 Ohyama Makoto;Tabata Yuji;Iida Maiko;Kaneda Kaori;Takahata Sho
分类号 A61K31/415;C07D231/10;C07D207/32;C07D231/12;C07D231/14;C07D231/22;C07D207/34;C07D207/36 主分类号 A61K31/415
代理机构 Holtz, Holtz, Goodman & Chick PC 代理人 Holtz, Holtz, Goodman & Chick PC
主权项 1. A compound represented by the following formula (I), wherein: R1 represents a hydrogen atom, a C1-6alkyl or a trifluoromethyl group; R2 represents a hydrogen atom, a C1-6alkyl, a halogen, a —COO(C1-6alkyl) or a —(CH2)1-3COOR group, wherein R represents a hydrogen atom or a C1-6alkyl; R3 represents a hydrogen atom, a C1-6alkyl, an amino, a trifluoromethyl group or an —OR group, R represents a hydrogen atom or a C1-6alkyl; R4 represents a hydroxyl group; R5 represents a hydrogen atom, a C1-6alkyl, a hydroxyl group or a halogen; R6 represents a C1-6alkyl, a trifluoromethyl group, a halogen, an amino group, a —NRaRb group, a nitro group, a hydroxy C1-6alkyl, a —CONRaRb group, a —COO(C1-6alkyl), a —COOH, a —(CH2)1-3COOR group, or an —ORa group, wherein R represents a hydrogen atom or a C1-6alkyl, and Ra and Rb are the same or different from each other and represent a hydrogen atom, a C1-6alkyl or a C1-6acyl; R7 represents a hydrogen atom, a C1-6alkyl, an —OR group, wherein R represents a hydrogen atom or a C1-6alkyl; and R8 represents a hydrogen atom, a C1-6alkyl, a hydroxyl group, an amino group or a nitro group, with the proviso that when R1 is a hydrogen atom, R3 is not a hydrogen atom, and the compound wherein R1 is tert-butyl group, R3 is an amino group, R4 is a hydroxyl group and R6 is a methyl group is excluded, or a salt thereof
地址 Tokyo JP