NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF

摘要

Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.

主权项

1. A benzamide derivative represented by Formula 1 below or pharmaceutically acceptable salt thereof: (wherein R1 is NHR6, R2 is hydrogen, (C1-C6) alkyl or (C1-C6) alkoxy; R3 is hydrogen, (C1-C6) alkyl or (C1-C6) alkoxy having at least one hydrogen atom substituted or unsubstituted with halogen; R4 is hydrogen, hydroxyl group, amino group (NH2), (C1-C6) alkoxy, (C3-C6) aromatic cycloalkoxy, (C3-C6) aliphatic cycloalkoxy, or (C1-C6) alkylalkoxy having at least one (C3-C6) aromatic ring or aliphatic ring; R5 is hydrogen, (C1-C6) alkyl, (C1-C6) alkoxy or halogen; R6 is CH2R11, CH2CHR12R13, quinuclidine, naphthalene having at least one carbon atom substituted with N, R11 is a (C5-C6) aliphatic cyclic or aromatic cyclic compound or (C5-C6) aliphatic heterocyclic or aromatic heterocyclic compound having at least one carbon atom substituted with O or N, wherein the aliphatic ring, aromatic ring, aliphatic hetero-ring or aromatic hetero-ring of R11 may be one substituted with at least one substituent selected from a group consisting of; (C1-C6) alkyl, hydroxy, NR21R22, halogen and (C5-C6) aliphatic heterocyclic or aromatic heterocyclic compound having at least one carbon atom substituted with O or N, wherein R21 and R22 are independently each hydrogen, (C1-C6) alkyl or phenyl; R12 and R13 are independently each hydrogen, NR23R24, an (C5-C6) aliphatic cyclic or aromatic cyclic compound, or a (C5-C6) aliphatic heterocyclic or aromatic heterocyclic compound having at least one carbon atom substituted with O or N, wherein the aliphatic ring, aromatic ring, aliphatic hetero-ring or aromatic hetero-ring of R12 and R13 may be one substituted with at least one substituent of (C1-C6) alkyl or (C1-C6) alkoxy, wherein R23 and R24 are independently each hydrogen or (C1-C6) alkyl or, otherwise, are coupled together to form a (C5-C6) aliphatic cyclic or heterocyclic compound, or a (C5-C6) aliphatic heterocyclic or aromatic heterocyclic compound having at least one carbon atom substituted with O.