发明名称 |
Method for producing surfactin and salt thereof |
摘要 |
The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent,;wherein the surfactin or the salt thereof is represented by the formula (1):;
wherein * indicates an optically active center; X is an amino acid selected from leucine, isoleucine and valine; R is a C9-13 alkyl group or a C9-13 branched alkyl group; and M is an alkali metal, an alkaline earth metal, an optionally-substituted amine or the like. |
申请公布号 |
US8883968(B2) |
申请公布日期 |
2014.11.11 |
申请号 |
US201113876734 |
申请日期 |
2011.09.30 |
申请人 |
Kaneka Corporation |
发明人 |
Izumida Masashi;Kawasaki Hiroaki;Moroshima Tadashi |
分类号 |
C07K1/14;C07K1/30;C07K7/06;C07K1/36 |
主分类号 |
C07K1/14 |
代理机构 |
Novak Druce Connolly Bove + Quigg LLP |
代理人 |
Novak Druce Connolly Bove + Quigg LLP |
主权项 |
1. A method for producing a surfactin or a salt thereof, comprising the steps of adding an organic solvent containing a branched alkyl alcohol and an auxiliary solvent to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent,
wherein a total ratio of the branched alkyl alcohol and the auxiliary solvent is not less than 0.6 parts by weight and not more than 1.5 parts by weight relative to 1 part by weight of the culture fluid, and the surfactin or the salt thereof is represented by the formula (1): wherein * indicates an optically active center; X is an amino acid selected from leucine, isoleucine and valine; R is a C9-13 linear alkyl group or a C9-13 branched alkyl group; and M is a hydrogen, an alkali metal, an alkaline earth metal, or an optionally-substituted amine. |
地址 |
Osaka JP |