| 摘要 |
The present disclosure is directed to methods of achieving anticoagulation in a patient in need thereof. The typical patient is expected to be in need for anticoagulation treatment for an extended period of time, and therefore has an increased risk of developing heparin resistance. The method comprises administering a therapeutically effective amount of a direct thrombin inhibitor, such as argatroban. The disclosed methods are particularly suited for the treatment of critically ill patients who are expected to be in the need for an extended period of anticoagulation treatment, including but not limited to, ICU patients, and/or patients suffering from sepsis, SIRS, MODS, and/or MOF. |
