发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION |
摘要 |
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof. |
申请公布号 |
CA2921509(A1) |
申请公布日期 |
2014.11.06 |
申请号 |
CA20142921509 |
申请日期 |
2014.05.01 |
申请人 |
IONIS PHARMACEUTICALS, INC. |
发明人 |
PRAKASH, THAZHA P.;SETH, PUNIT P.;SWAYZE, ERIC E.;GRAHAM, MARK J. |
分类号 |
C07K14/775;A61K48/00;C12N15/113 |
主分类号 |
C07K14/775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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