PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

摘要

The invention features pharmaceutical compositions including (i) a drug, and (ii) a PEG fatty acid ester or PPG fatty acid ester in an amount sufficient to increase the oral bioavailability of the drug.

主权项

1. A pharmaceutical composition in oral dosage form comprising:
a) a drug; and b) an additive comprising a PEG fatty acid ester or PPG fatty acid ester, wherein said additive is present in an amount sufficient to increase the oral bioavailability of said drug, and wherein said pharmaceutical composition is (i) substantially free of monoglycerides; (ii) substantially free of diglycerides; (iii) substantially free of triglycerides; (iv) substantially free of free polyethylene glycol; (v) substantially free of free polypropylene glycol; (vi) substantially free of fatty acid; (vii) substantially free of glycerol; (viii) comprises a substantially pure PEG fatty acid ester; (ix) comprises a substantially pure PEG fatty acid monoester; (x) comprises a substantially pure PEG fatty acid diester; (xi) comprises a substantially monodisperse PEG fatty acid ester; (xii) comprises a substantially pure PPG fatty acid ester; (xiii) comprises a substantially pure PPG fatty acid monoester; (xiv) comprises a substantially pure PPG fatty acid diester; or (xv) comprises a substantially monodisperse PPG fatty acid ester.