| 发明名称 |
PROCESS FOR THE SYNTHESIS OF AMINAPHTONE |
| 摘要 |
The present invention concerns a new process for the synthesis of aminaphtone, which makes use of non-toxic solvents and reagents, under mild reaction and temperature conditions. The aminaphtone obtained with the method of the present invention also has a purity of at least 98% in weight. The method comprises the following steps: a) epoxidating menadione 1 to provide epoxide 2, b) acidifying epoxide 2 to provide hydroxynaphthoquinone 3, c) esterifying between hydroxynaphthoquinone 3 and 4-aminobenzoyl chloride to obtain compound 4, and d) reducing compound 4 in the presence of a reducing agent in water to obtain aminaphtone. |
| 申请公布号 |
US2014323747(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201414263911 |
申请日期 |
2014.04.28 |
| 申请人 |
LABORATORI BALDACCI SPA |
发明人 |
BALDACCI Massimo;Roberti Marinella |
| 分类号 |
C07C227/02;C07D303/12;C07C229/66 |
主分类号 |
C07C227/02 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for preparing aminaphtone, comprising the following steps:
a) epoxidating menadione 1to provide epoxide 2 b) acidifying epoxide 2 to provide hydroxynaphthoquinone 3 c) esterifying between hydroxynaphthoquinone 3 and the chloride of 4-aminobenzoyl of formulato obtain compound 4 d) reducing compound 4 in the presence of a reducing agent in water to obtain aminaphtone. |
| 地址 |
Pisa IT |
