发明名称 |
Transgene delivering retrovirus targeting collagen exposed at site of tissue injury |
摘要 |
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component. |
申请公布号 |
US8871734(B2) |
申请公布日期 |
2014.10.28 |
申请号 |
US201313959570 |
申请日期 |
2013.08.05 |
申请人 |
The University of Southern California |
发明人 |
Hall Frederick L.;Gordon Erilinda Maria |
分类号 |
C07H21/04;A61K48/00;C07K14/005;C12N15/86;C07K14/755 |
主分类号 |
C07H21/04 |
代理机构 |
Wilson Sonsini Goodrich & Rosati |
代理人 |
Wilson Sonsini Goodrich & Rosati |
主权项 |
1. A method of treating a disease associated with exposition of collagen of a host, comprising: directly or intravenously delivering to the host a retroviral particle comprising:
(a) a modified viral envelope protein wherein the viral envelope protein includes a receptor binding region, wherein the receptor binding region is modified to include a collagen binding domain, and (b) at least one polynucleotide encoding a therapeutic polypeptide;wherein the viral particle binds to exposed collagen and expresses the therapeutic polypeptide, whereby said disease is treated. |
地址 |
Los Angeles CA US |