Heterocyclic modulators of lipid synthesis

摘要

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

主权项

1. A compound of Structure (IX):or a pharmaceutically acceptable salt thereof, wherein:
R1 is H, —CN, halogen, C1-C4 straight or branched alkyl, —O—(C3-C5 cycloalkyl), —O—(C1-C4 straight or branched alkyl) wherein:
C3-C5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; andwhen R1 is not H, —CN or halogen, it is optionally substituted with one or more halogens; each R2 is independently hydrogen, halogen or C1-C4 straight or branched alkyl; R3 is H, —OH, or halogen; R21 is H, halogen, C1-C4 straight or branched alkyl, C3-C5 cycloalkyl wherein the C3-C5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; R22 is H, halogen, or C1-C2 alkyl; R24 is H, C1-C4 straight or branched alkyl, —(C1-C4 alkyl)t—OH,
—(C1-C4 alkyl)t—Ot—(C3-C5 cycloalkyl), or—(C1-C4 alkyl)t—O—(C1-C4 straight or branched alkyl) wherein:
t is 0 or 1;the C3-C5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom; L1 is N; and L2 is N.