| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of manufacturing 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5,7-dicarboxylic acid dialkyl ester with good selectivity and yield.SOLUTION: 3,4-dihydroxy thiophene-2,5-dicarboxylic acid ester and dihalogenated propanol is reacted in a presence of iodide and a base to obtain 2-hydroxymethyl-2,3-dihydro-thieno[3,4-b][1,4]dioxin-5,7-dicarboxylic acid dialkyl ester represented by the formula (3), R represents each independently an alkyl group having 1 to 4 carbon atoms. |
