SILICONE SCAR TREATMENT PREPARATION

摘要

Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.

主权项

1. A method for preparing a spreadable composition for topical application comprising:
(a) providing a volatile component, a volatile coagent, and an active component; and (b) mixing the volatile component, the volatile coagent, and the active component with siloxane matrix precursors thereby forming the spreadable preparation; wherein: (i) the volatile component being present in the composition at a concentration ranging from 12 wt % to 45 wt % of the overall composition;
(ii) the siloxane matrix precursors having dimethicone and dimethicone cross polymers and ranging from 25 wt % to 60 wt % of the overall composition;(iii) an active component comprising a corticosteroid or an agent having sun screening activity; and(iv) the volatile coagent being present in the composition at a concentration ranging from 5 wt % to 50 wt % of the overall composition.