发明名称 |
PROCESS FOR THE PREPARATION OF LAPATINIB |
摘要 |
<p>Present process relates to an improved and commercial process for the preparation of lapatinib of formula-I or its pharmaceutically acceptable p-toluenesulfonate salt involving novel intermediates of formulae-XVII, XVIII, and XIX. Present process utilizes Meerwein reaction as a key step in the aryl C-C bond formation step avoiding costly boronate coupling chemistry used in the conventional synthesis of lapatinib.</p> |
申请公布号 |
WO2014170910(A1) |
申请公布日期 |
2014.10.23 |
申请号 |
WO2014IN00210 |
申请日期 |
2014.04.03 |
申请人 |
NATCO PHARMA LIMITED |
发明人 |
MUDDASANI, PULLA REDDY;TALASILA, SAMBASIVA RAO;SATTI, VENKATA REDDY;NEKKANTI, SATISH CHOWDARY;NANNAPANENI, VENKAIAH CHOWDARY |
分类号 |
C07D405/04 |
主分类号 |
C07D405/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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