发明名称 |
CERAMIDES AND APOPTOSIS-SIGNALING LIGAND |
摘要 |
The invention provides the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent. |
申请公布号 |
CA2585645(C) |
申请公布日期 |
2014.10.21 |
申请号 |
CA20052585645 |
申请日期 |
2005.10.31 |
申请人 |
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT |
发明人 |
BIELAWSKA, ALICJA;HANNUN, YUSUF A.;NORRIS, JAMES;SZULC, ZDZISLAW;DONG, JIAN-YUN;BIELAWSKI, JACEK;SCHWARTZ, DAVID;HOLMAN, DAVID;EL-ZAWAHRY, AHMED;MCKILLOP, JOHN |
分类号 |
C07C205/00;C07D207/00;C07D211/00;C07D221/00;C07D233/00;C07D241/04 |
主分类号 |
C07C205/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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