Modified release pharmaceutical compositions

摘要

Disclosed herein are multiparticulate modified release pharmaceutical compositions comprising: (a) a first portion comprising an active ingredient, at least one surfactant and at least one release modifying agent and (b) a second portion comprising an active ingredient and optionally a release modifying agent. Particularly, the active ingredient in the first portion is a calcium channel blocker and the modified release composition is in the form of a multiparticulate tablet.

主权项

1. A multiparticulate modified release pharmaceutical composition comprising:
a first portion comprising
at least one active ingredient comprising a calcium channel blocker,at least one surfactant, andat least one release modifying agent; and a second portion mixed with the first portion, the second portion comprising
at least one active ingredient comprising a calcium channel blocker, andoptionally, at least one release modifying agent,the second portion having a different release profile than the first portion; the first portion having a form comprising a plurality of at least one selected from pellets, granules, microparticles, nanoparticles, and a combination thereof, the second portion having a form comprising a plurality of matrix granules, wherein the active ingredient of the first portion is released at pH above about 5.5, and release of the active ingredient of the second portion is pH independent.