| 发明名称 | Tetracycline compounds as tyrosyl-DNA phosphodiesterase I inhibitors | ||
| 摘要 | The instant invention is directed towards tetracycline compositions, and methods of inhibiting Tdp1 activity, and methods of treating Tdp1-associated disorders. | ||
| 申请公布号 | US8865686(B2) | 申请公布日期 | 2014.10.21 |
| 申请号 | US200812241011 | 申请日期 | 2008.09.29 |
| 申请人 | The United States of America, as Represented by the Secretary, Dept. of Health and Human Services | 发明人 | Pommier Yves;Thibaut Laurent;Marchand Christophe |
| 分类号 | A61K31/65;A61P35/00;C07D499/21;C07C237/26;C07D295/13 | 主分类号 | A61K31/65 |
| 代理机构 | Cantor Colburn LLP | 代理人 | Cantor Colburn LLP |
| 主权项 | 1. A method of inhibiting tyrosyl-DNA phosphodiesterase 1 activity in a subject, comprising administering to the subject in need thereof an effective amount of a compound ofor a combination thereof to inhibit tyrosyl-DNA phosphodiesterase 1 activity, the method further comprising administering to the subject a Topoisomerase I inhibitor. | ||
| 地址 | Washington DC US | ||