发明名称 |
METHOD OF TREATING ACNE |
摘要 |
An improved method for treating acne is described. The method involves 16-week, once daily, oral administration of about 40 mg doxycycline in a pharmaceutical composition containing about 30 mg doxycycline in an immediate release portion and about 10 mg doxycycline in a delayed release portion. It was surprisingly discovered that the 16-week, once daily, oral administration of about 40 mg doxycycline has achieved same or superior efficacy than that of 100 mg doxycycline, but with a significant reduction in adverse events. |
申请公布号 |
US2014309198(A1) |
申请公布日期 |
2014.10.16 |
申请号 |
US201414245666 |
申请日期 |
2014.04.04 |
申请人 |
MANNA Vasant Kumar;SEGURA Sandrine;BUSSARD Ludovic;ETCHEGARAY Jean-Pierre;FREIDENREICH Philip |
发明人 |
MANNA Vasant Kumar;SEGURA Sandrine;BUSSARD Ludovic;ETCHEGARAY Jean-Pierre;FREIDENREICH Philip |
分类号 |
A61K9/48;A61K9/28;A61K31/65 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating acne in a subject in need of the treatment, comprising orally administering to the subject once daily a pharmaceutical composition comprising about 40 mg doxycycline or a pharmaceutically acceptable salt thereof, wherein the subject is treated for about 16 weeks; and wherein the pharmaceutical composition comprises about 30 mg doxycycline in an immediate release portion and about 10 mg doxycycline in a delayed-release portion. |
地址 |
Ewing NJ US |